Studies of inhibition of rat spermidine synthase and spermine synthase
نویسندگان
چکیده
منابع مشابه
Specificity of mammalian spermidine synthase and spermine synthase.
1. The specificity of rat prostatic spermidine synthase and spermine synthase with respect to the amine acceptor of the propylamine group was studied. 2. Spermidine synthase could use cadaverine (1,5-diaminopentane) instead of putrescine, but the Km for cadaverine was much greater and the rate with 1mM-cadaverine was only 10% of that with putrescine. 1,3-Diaminopropane was even less active (2% ...
متن کاملConsequences of Spermine Synthase or Spermidine/Spermine N- Acetyltransferase Deficiency in Polyamine Metabolism
A vast number of studies have linked polyamines to numerous cellular functions but less is known about the possible physiological functions of the individual polyamines. The specific gene targeting technique has provided a new potential way to resolve this mystery. We generated two separate embryonic stem (ES) cell lines where either spermine synthase gene (SPMSy) or spermidine/spermine N-acety...
متن کاملpostnatal studies of bats (pipistrellus kuhlii and miniopterus schreibersii) & histomorphology and histochemistry studies of organs and diseases of (neurergus microspilotus and n. kaiseri)
1. to determine whether difference in birth body mass influenced growth performance in pipistrellus kuhlii we studied a total of 12 captive-born neonates. bats were assigned to two body mass groups: light birth body mass (lbw: 0.89 ± 0.05, n=8) and heavy birth body mass (hbw: 1.35 ± 0.08, n=4). heavier body mass at birth was associated with rapid postnatal growth (body mass and forearm length) ...
Putrescine, Spermidine, and Spermine
Putrescine was first isolated from putrifying meat and was thought of as a decomposition product; spermine was named from its occurrence in semen. These polyamines, however, are now known to have important roles in cell growth and differentiation. Their physiological significance can be studied by analyzing the consequences of depletion of the cellular polyamine content. The results include arr...
متن کاملSpermine and Spermidine
1Plant Breeding Institute, ARC, SF-31600 Jokioinen, Finland; 2Department of Genetics, SF-00014 University of Helsinki, Helsinki, Finland In a recent article describing the effects of various reaction conditions, Blanchard et al. ~1~ ment ioned that spermine and spermidine at concentrations between 0.5 and 3 mM had no effect on PCR amplification ~2'3> with their sequence-specific primers. Becaus...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1980
ISSN: 0264-6021
DOI: 10.1042/bj1870419